Granulation synthesis and applications of granulation

Granulation synthesis

According to the help of the liquid in the granulation process, the granulation methods in the world are divided into dry granulation method and wet granulation method. In a Dry Granulator, instead of added water or other solvent and a mixed suspension as binder and solution to provide that required bond strength and cohesion of the particles in pow form, the powder is compacted by mechanical pressure, an external mechanical force is used to form patches or strips, which are then rolled and pulverized through a sieve

Simulation of granulation processes

The use of mathematical modelling tools for process simulation is becoming increasingly common in the pharmaceutical industry, particularly in drug granulation processes. Mathematical modelling tools can enhance the understanding of granulation processes by simulating processes that calculate the interactions between powders and powders and between particles, capturing underlying physical phenomena through fundamental first principles such as mass, momentum and energy.

Applications of granulation

Granulation technology is widely used in the preparation of bulk, granules, capsules, tablets and even dry powder inhalers. The application of this technology greatly increases the homogeneity and fluidity of the mixture of pharmaceutical raw materials in the preparation process, and also allows the adjustment of the disintegration and dissolution of tablets. In addition, it has many other functional advantages.